Obesity is a worldwide health problem causally associated with several other conditions, most notably type 2 diabetes mellitus, heart disease, and stroke. Researchers are working to identify genetic susceptibility to developing obesity and diabetes, mechanisms mediating the expression of the susceptibility genes, mechanisms causing resistance to insulin, factors causing progressive loss of insulin-producing cells, and the nature, prevention and management of the serious complications of diabetes including kidney insufficiency, visual loss, and coronary artery disease.
The mission of the Center for Diabetes and Metabolism Research is to advance the understanding of the mechanisms involved in the pathogenesis of obesity and its complications and co-morbidities through:
identifying key genes and how, interacting with the environment, they cause these health problems
identifying potential targets for preventive or therapeutic interventions
translating basic research in preventive and therapeutic interventions through clinical trials to improve the health of the people in our communities.