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Christopher N. Otis, MD

Pathology Department   Image  
  • Professor of Pathology and Assistant Clinical Professor of Obstetrics and Gynecology, Tufts University School of Medicine
  • Director, Division of Surgical Pathology
  • Director, Division of Immunohistochemistry
Department of Pathology
759 Chestnut Street
Springfield, MA 01199
  • Sabbatical
    Pathology Section, National Cancer Center/National Institutes of Health
    Bethesda, MD
  • Surgical Pathology Fellowship
    Yale University School of Medicine
    New Haven, CT
  • Anatomic Pathology Residency
    Yale University School of Medicine
    New Haven, CT
  • Yale University School of Medicine
    New Haven, CT


Honors and Awards
  • Academic Achievement Award, Baystate Medical Center, 2005
  • Residency Teaching Award- Teacher of the Year, Department of Pathology, Baystate Medical Center, 2010
  • The Association of Directors of Anatomic and Surgical Pathology (past president)
Areas of Interest
  • Gynecologic Pathology
  • Breast Pathology
  • Pulmonary Pathology
  • Immunohistochemistry
  • Molecular Pathology
  • Medical Informatics
  • Cell Signal Protein Expression in Neoplasia
  • Epigenetic Alterations in Neoplasia
  • Graduate Medical Education
  • Error Reduction in Diagnostic Pathology
Committee Appointments
  • Scientific Advisory Board, Pioneer Valley Life Science Institute (Baystate)
Professional Service
  • Graduate Medical Education Committee, College of American Pathologists
  • Cancer Committee (Gynecologic Pathology sub-section leader), College of American Pathologists
  • Digital Pathology Working Group, College of American Pathologists
  • Lung Cancer Working Group, College of American Pathologists- Association of Molecular Pathology, Internation Association for the Study of Lung Cancer
  • Lower Anogenital Squamous Terminology Working Group, College of American Pathologists and the American Association for Colposcopy and Cervical Pathology
  • Internation Collaboration on Cancer Reporting, College of American Pathologists, Canadian Association of Pathology, RCPath, RCPA
  • Diagnostic Error Reduction Working Group, College of American Pathologists
  • Ambassador Program, United States and Canadian Academy of Pathology
  • Editorial Board, The American Journal of Clinical Pathology
  • Editorial Board, Cancer Cytopathology
  • Editorial Board, The Journal of Pathology Informatics

Peer Reviewed Papers

  • Assaad MW, Pantanowitz L, Otis CN. Diagnostic accuracy of image-guided percutaneous fine needle aspiration biopsy of the mediastinum. Diagn Cytopathol 2007;35(11):705-709.
  • Hollowell ML, Goulart RA, Gang DL, Otis CN, Prior J, Sachs BF, et al. Cytologic features of mullerian papilloma of the cervix: mimic of malignancy. Diagn Cytopathol 2007;35(9):607-611.
  • Pantanowitz L, Otis CN. Myxoid liposarcoma. Diagn Cytopathol 2007;35(5):283-284.
  • Blackburn AC, Hill LZ, Roberts AL, Wang J, Aud D, Jung J, Nikocheva T, Allard J, Peltz G, Otis CN, Cao JQ, Ricketts RS, Naber SP, Mollenhauer J, Poustka A, Malamud D, Jarry DJ. Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk. Am J Pathol 2007;170(6):2030-2041.
  • Modem RR, Otis CN, Florence RR, Pantanowitz L. Intestinal type adenocarcinoma in situ of the cervix. Diagn Cytopathol 2007;35(9):584-585.
  • Gozgit JM, Pentecost BT, Marconi SA, Ricketts-Loriaux RS, Otis CN, Arcaro KF. PLD1 is overexpressed in an ER-negative MCF-7 cell line variant and a subset of phospho-Akt-negative breast carcinomas. Br J Cancer 2007;97(6):809-817.
  • Pantanowitz L. and Otis CN.  Cystitis glandularis.  Diagn Cytopathol  2008;36:181-182
  • Pantanowitz L, Henneberry JM, Otis CN, Zachary M. Adenolipoma of the external female genitalia. Int J Gynecol Pathol. 2008;27:297-300
  • Piragua SC, Otis CN, Prefontaine M, Pantanowitz L. Cystic struma ovarii (with macrocystic change). Int J Surg Pathol. 2008;16:433-434.
  • Pantanowitz L, Otis CN. Glypican-3 immunohistochemistry in the ovary. Histopathology. 2008;53:115-117.
  • Pinco J, Goulart RA, Otis CN, Garb J, Pantanowitz L.  Impact of digital image manipulation in cytology. Arch Pathol Lab Med. 2009;133:57-61.
  • Caponetti GC, Pantanowitz L, Marconi S, Havens JM, Lamps LW, Otis CN.  Evaluation of immunohistochemistry in identifying Bartonella henselae in cat scratch disease.  Am J Clin Pathol 2009;131:250-256.
  • Camelo-Piragua SI, Habib C,  Kanumuri, P, Laga-Toro C, Mason, H, Otis, CN.  Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature.  Hum Pathol 2009;40:887-892.
  • Pantanowitz L, Otis CN, Dezube BJ.  Immunohistochemistry in Kaposi sarcoma.  Clin Exp Derm.  2009;35:68-72
  • Torlakovic EE, Riddell R, Hewlett B, Banerjee D, El-Zimaity H, Flynn G, Pilavdzic D, Dawe P, Magliocco A, Barnes P, Berendt R, Cook D, Gilks B, Williams G, Perez-Ordonez B, Wehrli B, Swanson PE, Otis CN,  Nielson S, Vyberg M, Butany J.  Best practice recommendations for the standardization of immunohistochemistry test.  The Canadian Association of Pathologists, national Standards Committee /Immunohistochemistry.  Canadian Journal of Pathology.  2009;1:14-24
  • Talbert ML, Ashwood ER, Brownlee NA, Clark JR, Horowitz RE, Lepoff RB, Neumann A, Otis CN, Powell SZ, Sodeman TM. Resident preparation for practice: a white paper from the College of American Pathologists and Association of Pathology Chairs. Arch Pathol Lab Med. 2009;133:1139-1147.
  • Pantanowitz L, Otis CN, Goulart RA. Cytologic findings of psammocarcinoma in peritoneal washings. Acta Cytol. 2009;53:263-267.
  • Doldan A, Otis CN, Pantanowitz L. Adipose tissue: a normal constituent of the uterine cervical stroma. Int J Gynecol Pathol. 2009;28:396-400.
  • Yan H, Blackburn AC, McLary C, Xavier EA, Tao L, Dickinson ES, Roberts AL, Seo JH, Otis CN, Cao QJ, Lawlor RG, Osborne BA, Kitrell FS, Medina D, Jerry JD.  Multiple pathways contribute to development of spontaneous mammary tumors in BALB/c Trp53+/- mice.  Am J Pathol.  2009;176:1421-32.
  • Torlakovic EE, Riddell R, Banerjee D, El-Zimaity H, Pilavdzic D, Dawe P, Magliocco A, Barnes P, Berendt R, Cook D, Gilks B, Williams G, Perez-Ordonez B, Wehrli B, Swanson PE, Otis CN, Nielsen S, Vyberg M, Butany J. Canadian Association of Pathologists-Association canadienne des pathologistes National Standards Committee/Immunohistochemistry: Best Practice Recommendations for Standardization of Immunohistochemistry Tests. Am J Clin Pathol 2010;133, 354-365.
  • Hewitt SM, Robinowitz M, Boenisch T, Bogen SA, Gown AM, Kalra KL, Otis CN, Spaulding B, Taylor CR.  Quality assurance for design control and implementation of immunohistochemical assays; 2nd edition.  Clinical and Laboratory Standards Institute.  I/LA28-A2.  2010.
  • Setia N, Goulart RA, Leiman G, Otis CN, Modem R, Pantanowitz L.  Cytomorphology of Cervicovaginal Melanoma: ThinPrep versus Conventional Papanicolaou Tests.  Cytopathology Journal  2010;7:25.
  • Browne WP, Punska EP, Lenington SL, Otis CN, AndertonDL and Arcaro KF.  Increased Promoter Methylation in Exfoliated Breast Epithelial Cells in Women with a Previous Breast Biopsy.  Epigenetics  2011;6 1425-1435.
  • Chapman CN, Otis CN.  From Critical Values to Critical Diagnoses:  a Review with Emphasis on Cytopathology.  Cancer Cytopathology 2011;119:148-157.
  • Kuperman M, Florence RR, Pantanowitz L, Visintainer P, Otis CN.  An Evidence Based approach to the diagnosis of malignant mesothelioma in cytologic effusions through detection of overexpression of glucose transporter molecule 1 and epithelial membrane antigen.  Diagn Cytopathol Early online view.  26 August 2011 DOI:  10.1002/dc.21784
  •  Pantanowitz L, Sinard JH, Fatheree LA, Henricks WH, Carter AB, Contis L, Beckwith BA, Evans AJ, Otis CN, Parwani AV.  Validating Whole Slide Imaging for Diagnostic Purposes in Pathology: Recommendations of the College of American Pathologists (CAP) Pathology and Laboratory Quality Center.  Final draft preparation (open comment period completed).  To be submitted to Arch Pathol Lab Med. 2012
  • Bennet ST, Brownlee NA, Clark JR, Johnson K, Lepoff RB, Otis CN, Powell S, Talento RV, Tucker JA, Talbert ML.  Orientation program characteristics and perceived impact on resident performance in pathology residency training programs in the United States.  From the Graduate Medical Education Committee of the College of American Pathologists.  Final Draft, 2011.
  • Nucci MR, Cin PD, Hollowell M, Otis CN,  Morton CC, Quade BJ.  Intravenous leiomyomatosis:  An unusual intermediate between benign and malignant smooth muscle tumors.  In progress.

Book Chapters

  • Otis CN, Saunders P.  Best Evidence.  In:  Marchevsky A, Wick MR eds.  Evidence Based Pathology.  1st ed.  New York, Springer Press.  2011.
  • Carter D, True L, Otis CN:  Histology of Serosal Membranes. In: Sternberg S, ed.  Histology for Pathologists.  4th ed. New York:  Raven Press.  2011 (in progress).