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Alan L. Schneyer, PhD

Medicine Department   Image  
General Medicine Division
  • Distinguished Scientist, Pioneer Valley Life Sciences Institute
  • Research Professor, Tufts University School of Medicine
3601 Main Street
Springfield, MA 01199
Areas of Interest
  • New regulators of glucose homeostasis and insulin sensitivity
Professional Service
  • Member, Diabetes and Metabolism Working Group
  • Member, Center of Excellence in Apoptosis Research
  • Mukherjee A, Sidis Y, Mahan A, Raher MJ, Xia Y, Rosen ED, Bloch K, Thomas MK, and Schneyer AL. FSTL3 deletion reveals roles for TGFß family ligands in glucose and fat homeostasis in adults. Proc Nat Acad Sci; 2007; 104:1348-53.
  • Sidis Y, Mukherjee A, Keutmann HK, Delbaere A, Sadatsuki M, Schneyer A. Biological activity of follistatin isoforms and follistatin like-3 are dependent on differential cell surface binding and specificity for activin, myostatin and BMP’s. Endocrinology. 2006;147:3586-97.
  • Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf J, Andrews NC, Lin HY. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nature Genetics. 2006;38:531-9.
  • Saito S, Sidis Y, Mukherjee A, Xia Y, Schneyer A. Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3. Endocrinology. 2005;146(12):5052-62.
  • Welt CK, Taylor AE, Fox J, Messerlian GM, Adams JM, Schneyer AL. Follicular arrest in polycystic ovary syndrome is associated with deficient inhibin A and B biosynthesis. J Clin Endocrinol Metab. 2005;90(10):5582-7.
  • Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY. Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem. 2005;280(33):29820-7.
  • Xia Y, Sidis Y, Mukherjee A, Samad TA, Brenner G, Woolf CJ, Lin HY, Schneyer A. Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis. . Endocrinology. 2005;146(8):3614-21.
  • Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ. DRAGON, a bone morphogenetic protein co-receptor. J Biol Chem. 2005;280(14):14122-9.
  • Sidis Y, Schneyer AL, Keutmann HT. Heparin and activin-binding determinants in follistatin and FSTL3. . Endocrinology. 2005;146(1):130-6.
  • Del Re E, Sidis Y, Fabrizio DA, Lin HY, Schneyer A. Reconstitution and analysis of soluble inhibin and activin receptor complexes in a cell-free system. J Biol Chem. 2004;279(51):53126-35.
  • Schneyer AL, Wang Q, Sidis Y, Sluss PM. Differential distribution of follistatin isoforms: Application of a new FS315-specific immunoassay. J Clin Endocrinol Metab. 2004;89:5067-75.
  • Keutmann HT, Schneyer, A, Sidis Y. The role of follistatin domains in follistatin biological action. Molec Endocrinol. 2004;18:228-240.
  • Xia Y, Sidis Y, Schneyer A. Overexpression of follistatin like-3 (FSTL3) in gonads causes defects in gonadal develoment and function in transgenic mice. Molec Endocrinol. 2004;18:979-94.
  • Del Re E, Babitt JL, Pirani A, Schneyer A, Lin HY. In the absence of type III receptor, the TGFß type II-B receptor requires the type I receptor to bind TGFß2. J Biol Chemistry. 2004;279:22765-72.
  • Sidis Y, Tortoriello DV, Holmes WE, Pan Y, Keutmann HT, Schneyer AL. Follistatin-related protein and follistatin differentially neutralize endogenous vs. exogenous activin. Endocrinology. 2002;143(5):1613-24.
  • Fujiwara T, Sidis Y, Welt C, Lambert-Messerlian G, Fox J, Taylor A, Schneyer A. Dynamics of inhibin subunit and follistatin mRNA during development of normal and polycystic ovary syndrome follicles. J Clin Endocrinol Metab. 2001;86(9):4206-15.
  • Tortoriello DV, Sidis Y, Holtzman DA, Holmes WE, Schneyer AL. Human follistatin-related protein: a structural homologue of follistatin with nuclear localization. Endocrinology. 2001;142(8):3426-34.
  • Sidis Y, Schneyer AL, Sluss PM, Johnson LN, Keutmann HT. Follistatin: essential role for the N-terminal domain in activin binding and neutralization. J Biol Chem. 2001;276(21):17718-26.
  • Welt CK, Schneyer AL. Differential regulation of inhibin B and inhibin a by follicle stimulating hormone and local growth factors in human granulosa cells from small antral follicles. J Clin Endocrinol Metab. 2001;86(1):330-6.